Coherent X-ray Nano-CT for Bone Research

Project Team and Collaborators

Irene Zanette, Martin Dierolf, Richard Clare, Juliana Martins, Björn Enders, Marco Stockmar, Franz Pfeiffer Chair for Biomedical Physics, Technische Universitaet Muenchen, Germany

Pierre Thibault Department of Physics and Astronomy, University College London, London, United Kingdom

Andreas Menzel, Ana Diaz, Oliver Bunk Swiss Light Source, Paul Scherrer Institut, Villigen, Switzerland

Michael Kerschnitzki, Wolfgang Wagermaier, Peter Fratzl, Max Planck Institute for Colloids and Interfaces, Potsdam, Germany

Project Synopsis

Artistic representation of a set of coherent x-ray diffraction patterns that are used to reconstruct a high-resolution nanoCT image of a bone sample, highlighting particularly the canaliculi network between osteocyte cells in the bone.

Many of the most important bone diseases - such as osteoporosis - are critically linked to structural changes of the material on the nanometer scale. Because light or electron microscopy can not penetrate bone deep enough, we develop an alternative x-ray method for nano-scale tomographic imaging using large scale synchrotron or laser facilities. We believe that our approach will e useful to learn about early nano-structural changes associated osteoporosis, and eventually lead to a better clinical treatment of the disease.

Funding

  • DFG Excellence Grant “Munich-Centre for Advanced Photonics”

For further information, please contact Dr. Irene Zanette.